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The eggs are fertilized in the laboratory using the father's sperm in a technique called in vitro fertilization (IVF). Embryos of the desired gender are implanted back in the mother's uterus.Prior to fertilization with IVF, the fertilized eggs can be genetically biopsied with preimplantation genetic diagnosis (PGD) to increase fertilization success.The technique is recommended for couples who will not accept a child of the undesired gender.Timing methods aim to affect the sex ratio of the resultant children by having sexual intercourse at specific times as related to ovulation.Embryos of the desired sex and with acceptable genetics are then placed back into the mother.The IVF/PGD technique is favored over the Ericsson method because of the stricter control of the offspring gender in the laboratory.Furthermore, in countries where there are discriminatory practices regarding women inheriting, owning, or controlling land by law, having a son ensures that the family will not have to worry about the legal aftermath if something were to happen to them.

The United Nations Population Fund states that “Local fertility restrictions and spontaneous rapid fertility decline below replacement levels tend to compel parents who want both a son and a small family size to resort to sex selection.” In many cultures, male offspring are desired in order to inherit property, carry on the family name and to provide support for parents in old age.

Since only embryos of the desired sex are transferred to the mother, IVF/PGD avoids the small likelihood present in the Ericsson method of an undesired sperm fertilizing the egg.

Gender selection success rates for IVF/PGD are very high.

Men's preference for sons was most pronounced among men aged 18 to 29.

Women, on the other hand, showed no preference for either sex, with 33% stating that they preferred a girl and 31% responding that they favored a boy.

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